Our Research
The mammalian 12h-oscillator regulates genetic information flow
Nuclear speckle in proteostasis control and as a therapeutic target for proteinopathy, neurodegeneration and aging
Nuclear speckle in proteostasis control and as a therapeutic target for proteinopathy, neurodegeneration and aging
One main area of research in our lab focuses on elucidating the function and regulation of the mammalian 12h oscillator.
Nuclear speckle in proteostasis control and as a therapeutic target for proteinopathy, neurodegeneration and aging
Nuclear speckle in proteostasis control and as a therapeutic target for proteinopathy, neurodegeneration and aging
Nuclear speckle in proteostasis control and as a therapeutic target for proteinopathy, neurodegeneration and aging
Another area of research is using the 12h-oscillator as a discovery tool to unveil hidden principles of proteostasis and mRNA metabolism. Using this approach, we recently uncovered a pivotal role of nuclear speckles in proteostasis control.
Dysregulation of spatiotemporal control of genetic information flow in aging and diseases
Dysregulation of spatiotemporal control of genetic information flow in aging and diseases
Dysregulation of spatiotemporal control of genetic information flow in aging and diseases
We hypothesize that the dysregulation of 12h rhythms of proteostasis and mRNA metabolism (genetic information flow) is a driver of aging and aging-related diseases. We like to know how and why.
Bring your own research
Dysregulation of spatiotemporal control of genetic information flow in aging and diseases
Dysregulation of spatiotemporal control of genetic information flow in aging and diseases
Last but not the least, if you have great ideas, we would like to hear about it!