1. Lv B, Dion, W, Yang, H, Xun, J, Kim D, Zhu, B, and Tan JX. A TBK-independent primordial function of STING in lysosome biogenesis. Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.08.026
2. Kubra S, Sun M, Dion W, Catak A, Luong H, Wang H, Pan Y, Liu J, Ponna A, Sipula I, Jurczak MJ, Liu S, and Zhu B. Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health. bioRxiv (2024). DOI: https://doi.org/10.1101/2024.09.13.612812
3. Zhu B, Liu S, David NL, Dion W, Doshi NK, Siegel LB, Amorim T, Andrews RE, Kumar GVN, Li H, Irfan S, Pesaresi T, Sharma AX, Sun M, Fazeli PK, Steinhauser ML. Evidence for ~12-h ultradian gene programs in humans. npj Biol Timing Sleep. 2024;1(1):4. DOI: https://doi.org/10.1038/s44323-024-00005-1
4. Amorim, T., Kumar, N.GV., David, N.L., Dion, W., Pagadala, T., Doshi, N.K., Zhu, B., Parkhitko, A., Steinhauser, M.L., and Fazeli, P.K. Methionine and one carbon metabolism as a regulator of bone remodeling with fasting. JCI insight (2024). DOI: 10.1172/jci.insight.177997
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1. Jia M, Sayed K, Kapetanaki MG, Dion W, Rosas L, Irfan S, Valenzi E, Mora AL, Lafyatis RA, Rojas M, Zhu B, and Benos PV. LEF1 isoforms regulate cellular senescence and aging. Aging Cell (2023). DOI: https://doi.org/10.1111/acel.14024
2. Zhu B* and Liu S (*corresponding author). Preservation of ~12-hour ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock. Frontiers in Physiology (2023). DOI: https:// doi: 10.3389/fphys.2023.1195001
3. Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, Karri D, Zhu B, Yang F, Coarfa C, O’Malley BW, and Yi P. TRAF4- mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer. Proceedings of the National Academy of Sciences (2023) May 8. DOI: 10.1073/pnas.2218229120.
4. Zhu B*, Liu S, David NL, Dion W, Doshi NK, Siegel LB, Amorim T, Andrews RE, Kumar GVR, Irfan S, Pesaresi T, Sharma AX, Sun M, Fazeli PK, and Steinhauser ML *. (* co-corresponding authors). Evidence for conservation of a primordial 12-hour ultradian gene program in humans. bioRxiv (2023). DOI: https://doi.org/10.1101/2023.05.02.539021
5. Scott, MR, Zong W, Ketchesin KD, Seney ML, Tseng, GC, Zhu, B*, McClung CA*. (* co-corresponding authors). Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. PLoS Biology (2023). DOI: https://doi.org/10.1371/journal.pbio.3001688
[Featured in Science Daily: https://www.sciencedaily.com/releases/2023/01/230124192559.htm]
1. Dai T, Rosario SR, Katsuta E, Sawant Dessai A, Paterson EJ, Novickis AT, Cortes Gomez E, Zhu B, Liu S, Wang H, Abrams SI, Seshadri M, Bshara W, Dasgupta S. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Reports (2022); Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756
2. Rinsky, M., Weizman, E., Ben-Asher, HB. Eyal G., Zhu, B. and Levy, O. Temporal gene expression patterns in the coral Euphyllia paradivisa reveal the complexity of biological clocks in the cnidarian-algal symbiosis. Science Advances (2022). DOI: 10.1126/sciadv.abo6467
3. Meng, H, Gonzalez, N, Jung, SY, Lu Y, Putluri N, Zhu, B, Dacso, CC, Lonard, D and O'Malley BW. Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism. Cell Reports (2022); DOI: https://doi.org/10.1016/j.celrep.2022.110491
4. Dion, W., Ballance, H., Lee J., Pan Y., Irfan S., Edwards, C., Sun., M., Zhang J., Zhang X., Liu S. and Zhu, B. Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis. Science Advances (2022); DOI: 10.1126/sciadv.abl4150
[Featured in UPMC News Blog: https://inside.upmc.com/cellular-tides-influence-repair-of-faulty-proteins-involved-in-age-related-diseases/].
5. Zhu, B. Logic of the temporal compartmentalization of the hepatic metabolic cycle. Physiology (2022); https://doi.org/10.1152/physiol.00003.2022
6. Asher, G and Zhu, B. Beyond circadian rhythms: Emerging roles of ultradian rhythms in control of liver functions. Hepatology(2022); https://doi.org/10.1002/hep.32580
1. Moreno-Smith, M., Milazzo, G., Tao, L., Fekry B., Zhu, B., Mohammad M., Giacomo S., Borkar R., Reddy K., Capasso M., Vasudevan S., Sumazin P., Hicks, J., Putluri N., Perini G., Eckel-Mahan K., Burris T., and Barbieri E. Restoration of the molecular clock is tumor suppressive in neuroblastoma. Nature Communications (2021); DOI: https://doi.org/10.1038/s41467-021-24196-4
2. Ballance, H and Zhu, B. Revealing the hidden reality of the mammalian 12-h ultradian rhythms. Cellular and Molecular Life Sciences (2021); https://doi.org/10.1007/s00018-020-03730-5
1. Meng, H, Gonzalez, N, Lonard, D, Putluri N, Zhu, B, Dacso, CC, York, B and O'Malley BW. XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nature Communications (2020); DOI: https://doi.org/10.1038/s41467-020-20028-z
2. Sawant Dessai A, Palestino Dominguez M, Chen UI, Hasper J, Prechtl C, Yu C, Katsuta E, Dai T, Zhu B, Jung SY, Putluri N, Takabe K, Zhang XH, O'Malley BW, and Dasgupta S. Transcriptional repression of SIRT3 potentiates mitochondria aconitase activation to drive aggressive prostate cancer to bone. Cancer Research (2020); DOI: 10.1158/0008-5472.CAN-20-1708
3. Zhu, B. Decoding the function and regulation of the mammalian 12h-clock. Journal of Molecular Cell Biology(2020); doi: 10.1093/jmcb/mjaa021
4. Gao, Y., Chen, L., Han, Y., Wu F., Yang, W., Zhang, Z., Huo, T., Zhu, Y., Yu, C., Kim H., Lee M., Tang, Z., Philips, K., He, B., Jung, S.Y., Song, Y., Zhu, B., Xu, R. and Feng Q. Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. Communications Biology (2020); https://doi.org/10.1038/s42003-020-0898-0
5. Pan, Y, Ballance, H, Meng, H, Gonzalez, N, Kim, SM, Abdurehman, L, York, B, Chen, X, Schnytzer, Y, Levy, O, Dacso, CC, McClung, CA, O'Malley BW, Liu S, Zhu, B. 12-h clock regulation of genetic information flow by XBP1s. PLoS Biology (2020); DOI: 10.1371/journal.pbio.3000580
[Featured in UPMC News Blog: https://inside.upmc.com/what-do-a-mouse-an-ocean-snail-and-a-sea-anemone-have-in-common/].
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