12h oscillator dysregulation in aging and diseases

Preliminary results imply that the 12h-clock both regulates and responds to 12h-cycling metabolic stress cycles. Perturbation of metabolic homeostasis has been associated with a plethora of age-related diseases, including type 2 diabetes, cardiovascular diseases, hepatic steatosis and cancer. Disruption of a normal 12h rhythm of gene expression is highly associated with progression to non-alcoholic fatty liver diseases and aging in mouse liver. We aim to establish the causal relationships between the disruption of a 12h-clock with progression to metabolic diseases, aging-related diseases, and the aging process as a whole.